Annual report pursuant to Section 13 and 15(d)

Long-Term Debt and Other Financings - Interest Expense and Amortization of Debt Issuance Costs (Details)

v3.6.0.2
Long-Term Debt and Other Financings - Interest Expense and Amortization of Debt Issuance Costs (Details) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Interest expense and amortization of debt issuance costs [Abstract]      
Interest expense $ 3,946 $ 4,194 $ 4,303
Hercules Loan [Member]      
Interest expense and amortization of debt issuance costs [Abstract]      
Interest expense 2,628 2,223  
Servier Loan [Member]      
Interest expense and amortization of debt issuance costs [Abstract]      
Interest expense 892 1,083 2,330
GECC Term Loan [Member]      
Interest expense and amortization of debt issuance costs [Abstract]      
Interest expense   548 1,638
Novartis Note [Member]      
Interest expense and amortization of debt issuance costs [Abstract]      
Interest expense 405 329 312
Other [Member]      
Interest expense and amortization of debt issuance costs [Abstract]      
Interest expense $ 21 $ 11 $ 23