Annual report pursuant to Section 13 and 15(d)

Subsequent Events - Additional Information (Details)

v3.6.0.2
Subsequent Events - Additional Information (Details)
$ / shares in Units, € in Millions
 1 Months Ended 2 Months Ended 12 Months Ended
Jan. 09, 2015
EUR (€)
Feb. 28, 2017
USD ($)
$ / shares
shares
Jan. 31, 2017
EUR (€)
Mar. 14, 2017
USD ($)
shares
Dec. 31, 2016
USD ($)
$ / shares
shares
Dec. 31, 2015
USD ($)
$ / shares
shares
Dec. 31, 2014
USD ($)
shares
Oct. 31, 2016
$ / shares
Jan. 31, 2016
EUR (€)
Dec. 08, 2014
$ / shares
Subsequent Event [Line Items]                    
Proceeds from issuance of common stock | $         $ 57,000 $ 481,000 $ 41,442,000      
Common stock share price | $ / shares                   $ 98.80
Preferred stock, stated value | $ / shares         $ 0.05 $ 0.05   $ 0.05    
Servier Loan [Member]                    
Subsequent Event [Line Items]                    
Principal payment amount | €                 € 3.0  
Servier Loan [Member] | Tranche Two [Member]                    
Subsequent Event [Line Items]                    
Principal payment amount | € € 5.0                  
Maturity date Jan. 15, 2017                  
Common Stock [Member]                    
Subsequent Event [Line Items]                    
Sale of shares         13,000   405,000      
2015 ATM Agreement [Member]                    
Subsequent Event [Line Items]                    
Proceeds from issuance of common stock | $         $ 56,000          
2015 ATM Agreement [Member] | Common Stock [Member]                    
Subsequent Event [Line Items]                    
Sale of shares         10,365 0        
Subsequent Event [Member]                    
Subsequent Event [Line Items]                    
Maturity date     Jul. 15, 2017              
Proceeds from issuance of common stock and convertible preferred stock | $   $ 24,900,000                
Subsequent Event [Member] | 2010 Plan [Member]                    
Subsequent Event [Line Items]                    
Number of stock options granted to members of board, executives, and non-executive employees   1,018,000                
Subsequent Event [Member] | Series X Convertible Preferred Stock [Member]                    
Subsequent Event [Line Items]                    
Sale of shares   5,003                
Preferred stock, stated value | $ / shares   $ 4,030                
Conversion of preferred stock into registered common stock   1,000                
Preferred stock conversion price per share | $ / shares   $ 4.03                
Total number of shares of common stock issued upon conversion   5,003,000                
Percentage of convertible preferred stock conversion blocker provision   19.99%                
Subsequent Event [Member] | Asset Purchase Agreement and Nanotherapeutics License Agreement [Member]                    
Subsequent Event [Line Items]                    
Number of shares removed from obligation to issue of common stock   23,008                
Revised cash payments under license agreement | $   $ 4,500,000                
Contingent upon achieving certain specified future operating objectives | $   $ 3,000,000                
Subsequent Event [Member] | Servier Loan [Member] | Tranche Two [Member] | Amendment No.3 [Member]                    
Subsequent Event [Line Items]                    
Principal payment amount | €     € 5.0              
Maturity date     Jul. 15, 2017              
Subsequent Event [Member] | Common Stock [Member]                    
Subsequent Event [Line Items]                    
Sale of shares   1,200,000                
Common stock share price | $ / shares   $ 4.03                
Subsequent Event [Member] | 2015 ATM Agreement [Member]                    
Subsequent Event [Line Items]                    
Proceeds from issuance of common stock | $       $ 600,000            
Subsequent Event [Member] | 2015 ATM Agreement [Member] | Common Stock [Member]                    
Subsequent Event [Line Items]                    
Sale of shares       110,252