Annual report pursuant to Section 13 and 15(d)

Collaborative, Licensing and Other Arrangements - NIAID - Additional Information (Details)

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Collaborative, Licensing and Other Arrangements - NIAID - Additional Information (Details) - USD ($)
 1 Months Ended 12 Months Ended
Oct. 31, 2011
Sep. 30, 2008
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]            
Deferred revenue     $ 17,123,000 $ 18,000,000    
Recognition of revenue     379,000 2,268,000 $ 6,383,000  
National Institute of Allergy and Infectious Diseases "NIAID" [Member] | Arrangement with Governmental Agency 2 [Member]            
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]            
Total contract amount awarded   $ 64,800,000        
Recognition of revenue     100,000 0 200,000  
Contracts revenue wrote off     400,000      
National Institute of Allergy and Infectious Diseases "NIAID" [Member] | Arrangement with Governmental Agency 3 [Member]            
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]            
Contractual term   3 years        
Increase (decrease) in deferred revenue           $ 1,800,000
Deferred revenue           1,900,000
Remaining accounts receivable     400,000      
Remaining deferred revenue           $ 100,000
National Institute of Allergy and Infectious Diseases "NIAID" [Member] | Arrangement with Governmental Agency 1 [Member]            
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]            
Total contract amount awarded $ 28,000,000          
Contractual term 5 years          
Recognition of revenue     $ 0 $ 1,100,000 $ 4,900,000