Annual report pursuant to Section 13 and 15(d)

Concentration of Risk, Segment and Geographic Information - Revenue by Geographical Region (Details)

v3.8.0.1
Concentration of Risk, Segment and Geographic Information - Revenue by Geographical Region (Details) - USD ($)
$ in Thousands
 3 Months Ended 12 Months Ended
Dec. 31, 2017
 [1]
Sep. 30, 2017
 [1]
Jun. 30, 2017
 [1]
Mar. 31, 2017
 [1]
Dec. 31, 2016
Sep. 30, 2016
Jun. 30, 2016
Mar. 31, 2016
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Revenues from External Customers and Long-Lived Assets [Line Items]                      
Revenues $ 5,357 $ 36,183 $ 10,890 $ 260 $ 524 $ 635 $ 443 $ 3,962 $ 52,690 $ 5,564 $ 55,447
United States [Member]                      
Revenues from External Customers and Long-Lived Assets [Line Items]                      
Revenues                 1,654 3,822 10,685
Europe [Member]                      
Revenues from External Customers and Long-Lived Assets [Line Items]                      
Revenues                 50,936 1,642 44,662
Asia Pacific [Member]                      
Revenues from External Customers and Long-Lived Assets [Line Items]                      
Revenues                 $ 100 $ 100 $ 100
[1] In the third quarter of 2017, total revenues include upfront and milestone payments relating to various out-licensing arrangements, including $35.4 million of license fee revenue recognized in connection with the license agreements with Novartis, and, in the second quarter of 2017, total revenues include a $10.0 million milestone earned under the license agreement with Novartis International.