Annual report pursuant to Section 13 and 15(d)

Long-Term Debt and Other Financings - Interest Expense and Amortization of Debt Issuance Costs (Details)

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Long-Term Debt and Other Financings - Interest Expense and Amortization of Debt Issuance Costs (Details) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Interest expense and amortization of debt issuance costs [Abstract]      
Interest expense $ 1,238 $ 3,946 $ 3,765
Hercules Loan [Member]      
Interest expense and amortization of debt issuance costs [Abstract]      
Interest expense 311 2,628 2,223
Servier Loan [Member]      
Interest expense and amortization of debt issuance costs [Abstract]      
Interest expense 431 892 1,083
Novartis Note [Member]      
Interest expense and amortization of debt issuance costs [Abstract]      
Interest expense 490 405 329
Other [Member]      
Interest expense and amortization of debt issuance costs [Abstract]      
Interest expense $ 6 $ 21 $ 130