Annual report pursuant to Section 13 and 15(d)

Collaborative, Licensing and Other Arrangements - Pfizer - Additional Information (Details)

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Collaborative, Licensing and Other Arrangements - Pfizer - Additional Information (Details) - Collaborative Arrangement [Member] - Pfizer Inc. [Member] - USD ($)
12 Months Ended 60 Months Ended
Dec. 03, 2015
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]        
Milestone received under the collaboration agreement       $ 4,200,000
Amount received from settlement of the Pfizer agreement $ 3,800,000      
Royalties earned from sale   $ 0 $ 400,000