Annual report pursuant to Section 13 and 15(d)

Collaborative, Licensing and Other Arrangements - Sale of Future Revenue Streams - Additional Information (Details)

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Collaborative, Licensing and Other Arrangements - Sale of Future Revenue Streams - Additional Information (Details)
12 Months Ended
Dec. 21, 2016
USD ($)
Dec. 31, 2017
USD ($)
Agreement
Dec. 31, 2016
USD ($)
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]      
Deferred revenue – current   $ 1,413,000 $ 899,000
Deferred revenue, non-current   $ 17,123,000 18,000,000
HCRP [Member]      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]      
Number of royalty Interest acquisition agreements | Agreement   2  
Deferred revenue   $ 18,000,000  
Contract and other revenue   300,000  
Deferred revenue – current   600,000  
Deferred revenue, non-current   17,100,000 $ 18,000,000
HCRP [Member] | First Acquisition Agreement [Member]      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]      
Upfront cash payment received $ 6,500,000    
Eligible potential additional payments receivable upon achievement of specified net sales milestones in future years 4,000,000 3,000,000  
Milestone received under license agreement   $ 0  
HCRP [Member] | Second Acquisition Agreement [Member]      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]      
Upfront cash payment received $ 11,500,000