Annual report pursuant to Section 13 and 15(d)

CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS

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CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS - USD ($)
shares in Thousands, $ in Thousands
 12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Revenues:      
License and collaborative fees $ 3,296 $ 49,064 $ 5,683
Contract and other 2,268 6,383 13,183
Total revenues 5,564 55,447 18,866
Operating expenses:      
Research and development 44,234 70,852 80,748
Selling, general and administrative 18,322 20,620 19,866
Restructuring 4,566 3,699 84
Total operating expenses 67,122 95,171 100,698
Loss from operations (61,558) (39,724) (81,832)
Other income (expense):      
Interest expense (3,946) (4,194) (4,303)
Other income, net 1,510 5,500 2,061
Revaluation of contingent warrant liabilities 10,464 17,812 45,773
Net loss $ (53,530) $ (20,606) $ (38,301)
Basic net loss per share of common stock (in dollars per share) $ (8.89) $ (3.50) $ (7.13)
Diluted net loss per share of common stock (in dollars per share) $ (8.89) $ (3.50) $ (13.49)
Shares used in computing basic net loss per share of common stock (in shares) 6,021 5,890 5,372
Shares used in computing diluted net loss per share of common stock (in shares) 6,021 5,890 5,767
Other comprehensive loss:      
Net loss $ (53,530) $ (20,606) $ (38,301)
Net unrealized gain on available-for-sale securities     1
Comprehensive loss $ (53,530) $ (20,606) $ (38,300)