Annual report pursuant to Section 13 and 15(d)

Collaborative, Licensing and Other Arrangements - Servier - Additional Information (Details)

v3.6.0.2
Collaborative, Licensing and Other Arrangements - Servier - Additional Information (Details) - Collaborative Arrangement [Member] - Servier [Member]
€ in Millions, $ in Millions
 1 Months Ended 6 Months Ended 12 Months Ended
Jan. 09, 2015
EUR (€)
Jan. 31, 2011
USD ($)
Jan. 31, 2011
EUR (€)
Mar. 25, 2016
USD ($)
Dec. 31, 2016
USD ($)
Dec. 31, 2015
USD ($)
Dec. 31, 2014
USD ($)
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Upfront payment received | $   $ 15.0          
Proceeds from loan   $ 19.5 € 15.0        
Future initial research and development expenses to be funded by counterparty | $         $ 50.0    
Contract and other revenue | $         $ 0.6 $ 1.2 $ 3.5
Eligible milestone payments receivable | € € 356.5            
Eligible milestone payments receivable under specific rights not met | € 633.8            
Eligible milestone payments receivable, after amendment | € 341.5            
Eligible milestone payments receivable under specific rights not met, after amendment | € € 618.8            
Deferred revenue recognized | $       $ 0.6