Annual report pursuant to Section 13 and 15(d)

Collaborative, Licensing and Other Arrangements - Takeda - Additional Information (Details)

v3.6.0.2
Collaborative, Licensing and Other Arrangements - Takeda - Additional Information (Details) - USD ($)
$ in Thousands
1 Months Ended 12 Months Ended
Feb. 28, 2009
Nov. 30, 2006
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]          
Recognition of revenue     $ 3,296 $ 49,064 $ 5,683
Takeda [Member] | Sales Milestone [Member]          
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]          
Future milestone payments, maximum $ 3,300 $ 19,000      
Takeda [Member] | Development Milestone [Member]          
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]          
Future milestone payments with each additional future qualifying product candidate development, maximum     20,800    
Takeda [Member] | Collaborative Arrangement [Member]          
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]          
Recognition of revenue     $ 100 $ 100 $ 1,600
Royalty right expiration period 10 years 13 years 6 months