Quarterly report pursuant to Section 13 or 15(d)

Long-Term Debt - Servier Loan Agreement - Additional Information (Details)

v3.7.0.1
Long-Term Debt - Servier Loan Agreement - Additional Information (Details)
1 Months Ended 3 Months Ended 6 Months Ended
Jan. 09, 2015
USD ($)
Tranche
Jan. 31, 2017
USD ($)
Jan. 31, 2016
EUR (€)
Jan. 31, 2011
USD ($)
Jun. 30, 2017
USD ($)
€ / $
Jun. 30, 2016
USD ($)
Jul. 31, 2017
Jun. 30, 2017
USD ($)
€ / $
Jan. 31, 2017
USD ($)
Jun. 30, 2016
USD ($)
Jun. 30, 2017
EUR (€)
€ / $
Jan. 31, 2017
EUR (€)
Dec. 31, 2016
USD ($)
€ / $
Jan. 09, 2015
EUR (€)
Tranche
Debt Instrument [Line Items]                            
Accrued interest paid               $ 396,000   $ 1,127,000        
Carrying value of the loan         $ 27,861,000     $ 27,861,000            
Servier Loan [Member]                            
Debt Instrument [Line Items]                            
Date of agreement               Dec. 30, 2010            
Maximum borrowing capacity under loan agreement | €                     € 15,000,000      
Proceeds from loan       $ 19,500,000                    
Date of loan amendment               Jan. 09, 2015            
Date of agreement, after amendment               Aug. 12, 2013            
Number of tranches | Tranche 3                         3
Principal payment amount | €     € 3,000,000                      
Accrued interest paid | €     € 200,000                      
Unamortized discount on debt $ 1,900,000     $ 8,900,000                    
Amortization of debt discount         100,000 $ 200,000   $ 200,000   300,000        
Carrying value of the loan         13,500,000     13,500,000         $ 12,200,000  
Unrealized foreign exchange gains (loss) related to re-measurement of loan discount         14,000 (17,000)   20,000   20,000        
Outstanding principal balance         $ 13,700,000     $ 13,700,000         $ 12,600,000  
Euro to US Dollar exchange rates | € / $         1.142     1.142     1.142   1.052  
Unrealized foreign exchange gains (loss) related to re-measurement of loan         $ (900,000) $ 300,000   $ (1,100,000)   $ (200,000)        
Servier Loan [Member] | Tranche One [Member]                            
Debt Instrument [Line Items]                            
Maturity date Jan. 15, 2016                          
Principal payment amount | €                           € 3,000,000
Servier Loan [Member] | Tranche Two [Member]                            
Debt Instrument [Line Items]                            
Maturity date Jan. 15, 2017                          
Principal payment amount | €                           5,000,000
Servier Loan [Member] | Tranche Three [Member]                            
Debt Instrument [Line Items]                            
Maturity date Jan. 15, 2018                          
Principal payment amount | €                           € 7,000,000
Servier Loan [Member] | Mid-July 2016 Through Mid-January 2017 [Member]                            
Debt Instrument [Line Items]                            
Period of interest resetting                 6 months          
Interest rate during period                 1.81%          
Servier Loan [Member] | Amendment No.3 [Member] | Tranche Two [Member]                            
Debt Instrument [Line Items]                            
Maturity date   Jul. 15, 2017                        
Principal payment amount | €                       € 5,000,000    
Unamortized discount on debt   $ 400,000             $ 400,000          
Servier Loan [Member] | Forecast [Member] | Mid-January 2017 Through Mid-July 2017 [Member]                            
Debt Instrument [Line Items]                            
Period of interest resetting             6 months              
Interest rate during period             1.77%