Quarterly report pursuant to Section 13 or 15(d)

Long-Term Debt - Interest Expense and Amortization of Debt Issuance Costs (Details)

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Long-Term Debt - Interest Expense and Amortization of Debt Issuance Costs (Details) - USD ($)
$ in Thousands
 3 Months Ended 6 Months Ended
Jun. 30, 2017
Jun. 30, 2016
Jun. 30, 2017
Jun. 30, 2016
Interest expense and amortization of debt issuance costs [Abstract]        
Interest expense $ 297 $ 1,007 $ 906 $ 2,009
Hercules Term Loan [Member]        
Interest expense and amortization of debt issuance costs [Abstract]        
Interest expense   679 311 1,351
Servier Loan [Member]        
Interest expense and amortization of debt issuance costs [Abstract]        
Interest expense 178 225 355 451
Novartis Note [Member]        
Interest expense and amortization of debt issuance costs [Abstract]        
Interest expense $ 119 98 236 195
Other [Member]        
Interest expense and amortization of debt issuance costs [Abstract]        
Interest expense   $ 5 $ 4 $ 12